WHSC2 Antibody Catalog Number：OM295133

Product Profile

Product NameWHSC2 AntibodyAntibody TypePrimary AntibodiesProduct descriptionThis gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, ａnd may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted ａnd tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

More

ImmunogenThis WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.

Key Feature

ClonalityPolyclonalIsotypeIgHost SpeciesRabbitTested ApplicationsWB

For WB starting dilution is: 1:1000:

Species ReactivityHuman

Concentration1 mg/mlPurificationAffinity purified

Target Information

Gene SymbolNELFAAlternative NamesNegative elongation factor A

NELF-A

Wolf-Hirschhorn syndrome candidate 2 protein

NELFA

WHSC2

More Molecular Weight(MW)57 kDaSequence SimilaritiesPredicted species reactivity based on immunogen sequence: Mouse

Database Links

Entrez Gene7469Protein AccessionQ9H3P2

Application

ApplicationWestern blot analysis in NCI-H460 cell line lysates (35ug/lane).

Application NotesFor WB starting dilution is: 1:1000:

Additional Information

FormLiquidStorage InstructionsStore at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.Storage BufferSupplied in PBS with 0.09% (W/V) sodium azide.